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MAGE-G1 (melanoma-associated antigen G1, also designated necdin-like 2) gene encodes a necdin homologous protein. MAGE-G1 gene, similarly to necdin gene, has been mapped to the region of proximal chromosome 15q in human, which is subject to genomic imprinting and implicated in various human neurological and mental disorders (ref.1). From this finding it is suggested that MAGE-G1 is  involved in brain development, and its abnormality causes neurodevelopmental diseases, although its biochemical and functional features remain largely unknown. MAGE-G1 has characteristics similar to those of necdin, which suppresses cell growth by inducing cell cycle arrest. MAGE-G1, like necdin, targets both the transcription factor E2F1 and p75 neutrophin receptor (p75NTR) to regulate cell viability during brain development (ref.2). An antibody (named MG1) against mouse MAGE-G1 was raised in rabbit (ref.2).
 
Applications: 
1. Western blotting (1/3,000-1/1,000)   2. Immunoprecipitation.  3. Immunoaffinity purification 
Not tested for other applications

Immunogen: Recombinant MBT-fused mouse MAGE-G1 (aa 1-279). 
Reactivity:  Reacts with mouse, rat and human MAGE-G1.
Form: Antiserum added with 0.05% sodium azide.
Storage: Shipped at 4℃. Aliquot and store at -20℃
Data Link: Swiss-Prot Q9CPR8 (mouse), Q96MG7 (human)
References: This antibody was produced and used in ref.2.
1. Chibuk TK et al (2001) “A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues.” BMC Genet 2: 22 PMID: 11782285
2. Kuwako K et al. (2004) “Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neutrophin receptor.” J Biol Chem 279: 1703-1712　PMID: 14593116