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60+30+30min.

Detection Target name
alpha-Klotho

Target Synonyms
Klotho, KL, alpha-klotho, klotho peptide

Cross reactivity

Human alpha-Klotho; 100.0 %
Human osteopontin;   <0.1
Human VEGF (165);  <0.1
Human PDGF;             <0.1

Description

“alpha-klotho” was identified as an extremely down-regulated gene in the genetically-modified mouse of which phenotype is very similar to various symptoms of human aging. Then, the sequences of alpha-klotho genes have been identified in various species including humans based on the one of mouse. alpha-Klotho protein is a 130 kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands.
In recent years, it has become clear that alpha-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. Therefore, it is considered that, in alpha-klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of alpha-Klotho. Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of alpha-Klotho
protein is released free into blood by shedding. However, there are many unclear points about functions and changes in concentration of free (soluble) alpha-Klotho protein, so it has been required to develop the measurement system of alpha-Klotho.
This ELISA kit can measure Human soluble alpha-Klotho protein in human blood.

This product is useful for study about aging, minerals/calcium/phosphorus metabolism and homeostasis,v itamin D, carbohydrate metabolic process, bone mineralization, and etc.

※This product is available only in USA and Canada.