| Note | Detection Target name
Rat/mouse adiponectin
Target Synonyms
Adiponectin, Adipocyte C1q and collagen domain-containing protein, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein
Description
Mouse adiponectin is a molecule identified by the group of Lodish et al., Massachusetts Institute of Technology, in 1995 as an Acrp30 (adipose complement-related protein of 30kD) which is an analogue of complement component C1q induced during differentiation of mouse 3T3-L1 cell1). An adipoQ isolated from adipose cell differentiated from mouse 3T3-F442A cell by the group of Spiegelman et al. is the same molecule as Acrp302). On the other hand, adipocytokine identified by the group of Matsuzawa et al., Department of Internal Medicine and Molecular Science, Osaka University, in 1996 as a genetic apM13,4) (adipose most abundant gene transcript) expressed specifically in adipose tissues has 80% homology with Acrp30 and/or adipoQ in their amino acid sequences, which showing that they are the counterparts each other. In the recent study, it has been demonstrated that the Knock-out mouse in which adiponectin gene has been turned off is more likely to develop insulin resistance and arteriosclerotic lesion than wild-type mouse5). It is known that relationships between decrease in serum level of adiponectin and metabolic syndrome like diabetes mellitus6, 7), and arteriosclerosis6, 8) in human have been reported9). This kit is based on the enzyme-linked immunosorbent assay (ELISA) developed in a cooperative study with Matsuzawa, et al., and a recombinant mouse adiponectin is used as the reference standard. This kit enables measurement of adiponectin in mouse and/or rat serum and adipocyte extract or culture supernatant specifically, accurately, and simply.This product is useful for Diabetes / Obesity study. |
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